Advanced Biologics publishes additional OsteoAMP abstracts


Advanced Biologics has announced the publishing of two abstracts within The Bone and Joint Journal. Initially presented at the European Orthopaedic Research Society meeting, both abstracts further substantiate the differentiation and clinical benefit of OsteoAMP allograft-derived growth factor.

The first abstract, “Osteoinductivity and osteogenicity of leading allograft bone products”, examined the BMP-2 content and bone forming potential of OsteoAMP and Osteocel Plus (Nuvasive). In this athymic rat study, products were implanted and assessed for bone formation and measurement of the cellular, mineral, and collagen phase content of BMP-2. Osteocel Plus exhibited increased osteonecrosis over all time periods and no BMP-2 from cells on ELISA analysis. OsteoAMP on the other hand displayed approximately 1000 times the BMP-2 amounts of Osteocel Plus and new bone formation and cellularity increase through all time points.


“Our goal of this paper was to validate the anecdotal evidence we hear on a daily basis from the field,” comments Scott Cadotte, vice president of Sales and Marketing at Advanced Biologics. “This showcases the superiority of OsteoAMP over a leading allogeneic stem cell product and at a more cost-effective price.”


In the second abstract, “A blinded multicentre, clinical and radiological study to evaluate the efficacy of OsteoAMP versus rhBMP-2in TLIF/LLIF procedures”, a total of 254 consecutive patients (383 total levels) were treated with a TLIF or LLIF procedure and assessed radiologically. As has previously been shown, OsteoAMP produced faster fusion rates than rhBMP-2 and with much less radiologically evident adverse events such as osteolysis and ectopic bone formation.


OsteoAMP is an award winning allograft-derived growth factor that is a lower-cost alternative to recombinant growth factors, such as rhBMP-2 (Infuse, Medtronic) and allograft-derived stem cells, such as Osteocel Plus or Trinity Elite (Orthofix). OsteoAMP’s three distinctive formats (granules, compressible sponges and putty) provide a distinct advantage by allowing surgeons to tailor deliver the technology according to their needs in surgery.