Amniox Medical has announced results of a prospective randomised clinical study of its proprietary cryopreserved Amniotic Membrane as an adjunct to lumbar discectomy. The findings will be presented at the North American Spine Society 2016 annual meeting (26–29 October, Boston, USA), by the study’s lead investigator, D Greg Anderson, Rothman Institute, Philadelphia, USA.
The study included 80 patients, with half of the patients receiving Clarix 100 in the disc space following removal of the disc herniation and half receiving the standard of care which involved removal of the herniation alone. Patients treated with Clarix saw statistically significant improvement in Oswestry Disability Index (ODI) scores and SF-12 (Physical Composite Scale) at six weeks and two years, with the ODI quantifying disability due to low back pain and the SF-12 assessing patients’ physical and mental well-being. The study also reports that there were no recurrent herniations in the Clarix treatment group during the two-year follow-up period, compared to a 7.5% recurrence rate in the control group.
“Degenerative disc disease is the most common source of back pain and lumbar discectomy is the most common surgical intervention to treat this condition. However, residual back pain and recurrent herniations can be as high as 20%,” said Anderson, professor in the Departments of Orthopaedic and Neurological Surgery at Thomas Jefferson University and Clinical Director of the Spine Section of the Orthopaedic Research Laboratory. “These results indicate that the application of Clarix can influence the healing response to significantly improve post-surgical outcomes. Patients experience reduced pain and a faster and sustained return to activities of daily living. Additionally, although it was not an endpoint identified in the study protocol, we observed a reduction in the use of narcotics in the patients treated with Clarix.”
“This Level 1 study is the first one to evaluate the benefits of placental tissue in conjunction with discectomy and is clear evidence that the benefits of Clarix that have been observed in other orthopaedic procedures can be brought to patients undergoing spinal surgery” said Tom Dugan, chief executive officer of Amniox Medical. “Equally important to the clinical benefits observed are the enormous health economic implications of this study. Reductions in the rate of rehospitalisation and in the number of future operations for reherniation make this a technology that will be embraced by payers as well as providers.”