Neuroscientists have discovered a specific enzyme that plays a critical role in spinal muscular atrophy, and that suppressing this enzyme’s activity could markedly reduce the disease’s severity and improve patients’ lifestyles.
“We’ve identified the enzyme JNK3 as a therapeutic target to treat the symptoms of spinal muscular atrophy,” says Laxman Gangwani, an associate professor in the Center of Emphasis in Neuroscience at Texas Tech University Health Sciences Center El Paso, USA, who led the research.
In a recent study published in Human Molecular Genetics, Gangwani and his team of researchers at TTUHSC El Paso describe how mice with spinal muscular atrophy saw great improvement when the JNK3 enzyme was genetically inhibited to eliminate its activity. The finding suggests that patients with spinal muscular atrophy could also see improvement if treated with a drug that suppresses the activity of JNK3.
“We saw less muscle degeneration, more muscle growth and better muscle strength, and improvement in overall movement,” says Gangwani. “What’s more striking was a four-fold reduction in initial mortality period and a two-fold increase in total lifespan.”
This same study, however, found that inhibiting JNK3 in mice prevented the loss of motor neurons, which is particularly important to prevent progression of disease, says Gangwani.
“So far, spinal muscular atrophy research has focused on targeting the genetic mutation to prevent degeneration of spinal motor neurons, but it hasn’t been successful because of challenges associated with gene therapy,” he says. “This is the first study done that identifies a target, JNK3, that’s independent of the genetic mutation of spinal muscular atrophy for novel therapeutic development.”
The TTUHSC El Paso research team now plans to test pharmacological compounds that can inhibit JNK3 in mice to identify drug compounds that will slow the progression of the disease and reduce the overall burden of this illness in patients. They’ve also decided to patent their idea of using a JNK3 inhibitor to treat spinal muscular atrophy.
Gangwani says, “JNK3 represents a promising new avenue of research for clinical advances in developing a treatment.”