Until now, the role of galectins and their docking sites in osteoarthritis was largely unknown. In a study recently published in the Journal of Immunology, MedUni Vienna researchers have managed to identify the function of galectin-1 for the first time and establish that the carbohydrate-binding protein controls inflammation in the affected cartilage. The study has also been featured as a “Research Highlight” in the Nature Reviews Rheumatology.
“For the very first time our study showed that galectin-1 triggers inflammation rather than the inflammation triggering secretion of this protein,” explains Stefan Tögel, who is concerned with the glycobiology of orthopaedic diseases at the University Department of Orthopaedics. MedUni Vienna is one of the first research establishments in the world to conduct systematic research into this topic, according to a press release.
Galectin-1 is an example of a carbohydrate-binding protein in humans. In osteoarthritis, this protein is over-expressed in the joint cartilage—and the worse the degeneration of the joint, the more of it is secreted. Galectin-1 promotes inflammation by triggering the release of inflammatory factors via the NF-kB signalling pathway, which in turn contributes to destruction of the joint. “However, what we still don’t know is the answer to the question: why is galectin-1 so strongly expressed in the first place?” explains Tögel.
The glycobiologists at MedUni Vienna are already conducting further research to find out whether galectin-1 could be used in future as a target for preventive treatments or even as a possible biomarker for osteoarthritis.