New participant enrolled in Invivo Therapeutics’ INSPIRE study

InVivo Therapeutics' neuro-spinal scaffold
InVivo Therapeutics’ Neuro-spinal scaffold

InVivo Therapeutics has announced that a new patient has been enrolled into the INSPIRE study (InVivo Study of Probable Benefit of the Neuro-Spinal Scaffold for Safety and Neurologic Recovery in Subjects with Complete Thoracic AIS A Spinal Cord Injury) at Oregon Health & Science University (OHSU) in Portland, USA.

Ahmed M Raslan, and Jason J Chang, assistant professors of Neurological Surgery and study investigators, performed surgery and the implantation on the T9 neurologically complete patient approximately 36 hours after the injury occurred.

Mark Perrin, InVivo’s Chief Executive Officer and Chairman, says, “We are pleased that the patient is doing well and wish them continued recovery. We have nine patients enrolled and in follow up and, because we now have over 25 INSPIRE sites open, expect enrolment to increase in the coming months.”

InVivo Therapeutics has also added the University of Iowa Hospitals and Clinics in Iowa City, USA, and Allegheny General Hospital, Pittsburgh, USA, as clinical sites for the INSPIRE study.

University of Iowa Hospitals and Clinics is a 732-bed hospital which, in fiscal year 2015, received more than 57,000 emergency room visits.

“Two active areas of spinal cord injury research involve timing and the use of biomaterials. The INSPIRE study represents the marriage of these two concepts and we look forward to participating,” says Patrick Hitchon, professor in the departments of Neurosurgery and Biomedical Engineering and Principal Investigator at University of Iowa Hospitals and Clinics. Saul Wilson and Chandan Reddy are co-investigators for the research trial.

Allegheny General Hospital, which treats more than 24,000 inpatients each year, was the first hospital in the region to receive designation as a Level I Shock Trauma Center. This is the highest designation available.

“My research interests lie at the intersection of neuro-oncology and spinal disorders. While we routinely enter the spinal cord to remove tumours, the INSPIRE study is the first opportunity that affords us the ability to enter the spinal cord in trauma cases. I look forward to being a part of this study, which has the potential to change the standard of care,” says Terrence Julien, system director of Surgical Neuro-Oncology, system co-director of Minimally Invasive Spine Surgery, and principal investigator at the study site.

There are now 27 clinical sites participating in the clinical study:

Allegheny General Hospital, Pittsburgh, USA

Banner University Medical Center, Tucson, USA

Barnes-Jewish Hospital at Washington University Medical Center, St Louis, USA

Barrow Neurological Institute–St. Joseph’s Hospital and Medical Center, Phoenix, USA

Ben Taub Hospital/Baylor College of Medicine, Houston, USA

Beth Israel Deaconess Medical Center, Boston, USA

Carolina Neurosurgery and Spine Associates/Carolinas Rehabilitation, Charlotte, USA

Cooper Neurological Institute, Camden, USA

Foothills Medical Centre, Calgary, Canada

Goodman Campbell Brain and Spine/Indiana University Health Neuroscience Center, Indianapolis, USA

Hospital of the University of Pennsylvania, Philadelphia, USA

Keck Hospital of University of Southern California, Los Angeles, USA

Medical College of Wisconsin/Froedtert Hospital, Milwaukee, USA

Mount Sinai Hospital, New York, USA

Northwestern Medicine, Chicago, USA

Oregon Health & Science University, Portland, USA

Rutgers New Jersey Medical School, Newark, USA

Thomas Jefferson University Hospital, Philadelphia, USA

Toronto Western Hospital, Toronto, Canada

University of California, Davis Medical Center, Sacramento, USA

University of California, San Diego Medical Center, San Diego, USA

University of Iowa Hospitals and Clinics, Iowa City, USA

University of Kansas Medical Center, Kansas City, USA

University of Louisville Hospital, Louisville, USA

University of Pittsburgh Medical Center Presbyterian, Pittsburgh, USA

University of Virginia Health System, Charlottesville, USA

Vidant Medical Center, Greenville, USA