InVivo Therapeutics announces realignment of R&D strategy


As a result of an in-depth review of the company’s research and development portfolio, InVivo Therapeutics has announced that the company is realigning resources behind its novel Neuro-Spinal Scaffold and the Neuro-Spinal Scaffold Plus Stem Cells programme for spinal cord injury. Resources currently deployed towards InVivo’s hydrogel drug delivery programme will be eliminated.

The hydrogel platform was at an early stage of preclinical development, and substantial financial and human resources would have been required to address technical and competitive challenges and to advance any drug delivery product to the partnering stage or into the clinic. The company indicated that one element of the hydrogel platform will be further explored, the potential of hydrogel for cell delivery, as part of an expanded biomaterials development programme for the delivery of stem cells.

In announcing the refocusing of the company’s R&D resources, InVivo further announced it is making a reduction in force of 14 employees, or 28% of its workforce. The reduction in force and the shifting of R&D resources is expected to result in annualised savings of approximately US$3 million and to reduce cash expenditures by approximately 23% compared to 2013 levels. With these savings, InVivo anticipates that existing funds will be sufficient to support its planned activities through March 2016.

“Although reducing staff size and eliminating the hydrogel drug delivery programme were difficult decisions, InVivo’s focus will be even stronger on the company’s core mission: developing meaningful treatments for spinal cord injury,” chief executive officer Mark Perrin says. “Going forward, all of the company’s resources and efforts will be centred on the development of the Neuro-Spinal Scaffold for acute spinal cord injury and Scaffolds Plus Stem Cells for the treatment of chronic spinal cord injury. This focus will allow InVivo to advance the spinal cord injury programmes without distraction and in a more financially efficient manner. Developing effective spinal cord injury treatments is a challenging task, and our renewed focus maximises the potential for patients and shareholders to benefit from the major advancements that have been and continue to be made by the InVivo team.”