Early rehabilitation following a traumatic spinal cord injury may lead to better functional outcomes for patients at the time of their discharge and in the subsequent year, according to research presented this week at the Association of Academic Physiatrists Annual Meeting in Sacramento, USA.
Those patients who fall into longer acute-care stays, and begin rehabilitation later, may miss a window of opportunity to take advantage of neuroplasticity, or the brain’s ability to adapt to neurological changes and fine tune itself to meet the patient’s needs. This critical time period led researchers from Johns Hopkins University, Baltimore, the University of Alabama, Birmingham, USA and Northwestern University, Chicago, all USA, to examine patients’ outcomes after being discharged from rehabilitation as well as one year after their injury to determine if earlier rehabilitation can positively affect those outcomes when compared to rehabilitation later in the recovery process.
“We were interested in whether earlier rehabilitation would be associated with improved outcomes,” explains lead investigator, Kurt Herzer, a fellow in the Medical Scientist Training Program at Johns Hopkins School of Medicine, Birmingham, USA. “In other areas of medicine, we tend to recognise that the time between an acute health event and treatment matters. For example, many patients are familiar with the adage that ‘time is muscle’ following a heart attack, and that delays in treatment increase the likelihood of damage to the heart. Our study is interested in a similar type of relationship between time and outcomes, but extending to the post-acute care setting—the time from spinal cord injury to rehabilitation.”
Herzer’s team conducted a retrospective study using data from the Spinal Cord Injury Model Systems—a network of federally funded facilities that has collected data on demographic and clinical characteristics for approximately 13% of all spinal cord injury cases in the United States since 1973.
Herzer’s team looked at data for 3,937 people who sustained a traumatic spinal cord injury between 2000 and 2014. The patients were, on average, 41.5 years old at the time of their injury, and were admitted to a Spinal Cord Injury Model System facility within 24 hours of sustaining the injury.
The majority of those studied were white males (62.8% of the population was white and 79.2% was male), and nearly 17% had C1-C4 spinal cord injury, including paralysis in the hands, arms, trunk and legs.
The researchers looked at the number of days between the injury and admission to inpatient rehabilitation. They also looked at various measures to evaluate each patient’s outcome. These included the Functional Independence Measure (FIM) motor score at discharge and one-year post injury; discharge to a private residence; and the Craig Handicap Assessment and Reporting Technique (CHART) to assess physical independence and mobility at one-year post injury.
As they reviewed the data, the researchers took into consideration severity of illness. Additionally, they looked at Medicare data for terminally ill patients within different regions of the USA to better understand providers’ practice patterns within a given region and their likelihood of using acute care more versus less aggressively regardless of patients’ health statuses. “This additional information gave us the opportunity to improve our ability to make inferences about the relationship between time from injury to rehabilitation and subsequent outcomes,” explains Herzer with regards to the Medicare data reviewed.
Ultimately the team found that, for patients suffering from spinal cord injuries, earlier rehabilitation was associated with modest improvements in functioning and physical independence. More specifically, they found the average time to rehabilitation was 19 days during the time period studied. When they accounted for patients’ health statuses, they found that a 10% greater time to rehabilitation was associated with a relative decline of 4% in the FIM motor score and 5.3% in the CHART physical independence score at one-year post injury. Finally, they found no association between longer time to rehabilitation and the likelihood of being discharged to a private residence, one-year FIM motor score or the CHART mobility score.
“This study shows, following spinal cord injury, patients might benefit from entering inpatient rehabilitation at the earliest, clinically appropriate opportunity,” says Herzer of the results. “Patients and caregivers can discuss with their medical teams the plan and timing for transfer to rehabilitation and any concerns they may have about delays. Healthcare providers could similarly consider the value of additional days in the hospital as it relates to their treatment plans.”
The researchers caution that this observational study using data from the Spinal Cord Injury Model Systems has limitations, and that additional research is needed to establish a cause-and-effect relationship between timing of rehabilitation and outcomes. Additionally, Herzer notes an opportunity to identify possible solutions that could improve the likelihood that patients receive earlier rehabilitation. He says this will likely require improved communication between hospital providers and rehabilitation professionals, better education of hospital providers about the possible benefits of earlier rehabilitation, and enhanced discharge planning across the care continuum.
